ABSTRACT
Background: The current propagation models of COVID-19 are poorly consistent with existing epidemiological data and with evidence that the SARS-CoV-2 genome is mutating, for potential aggressive evolution of the disease. Objectives: We looked for fundamental variables that were missing from current analyses. Among them were regional climate heterogeneity, viral evolution processes versus founder effects, and large-scale virus containment measures. Methods: We challenged regional versus genetic evolution models of COVID-19 at a whole-population level, over 168,089 laboratory-confirmed SARS-CoV-2 infection cases in Italy, Spain, and Scandinavia at early time-points of the pandemic. Diffusion data in Germany, France, and the United Kingdom provided a validation dataset of 210,239 additional cases. Results: Mean doubling time of COVID-19 cases was 6.63 days in Northern versus 5.38 days in Southern Italy. Spain extended this trend of faster diffusion in Southern Europe, with a doubling time of 4.2 days. Slower doubling times were observed in Sweden (9.4 days), Finland (10.8 days), and Norway (12.95 days). COVID-19 doubling time in Germany (7.0 days), France (7.5 days), and the United Kingdom (7.2 days) supported the North/South gradient model. Clusters of SARS-CoV-2 mutations upon sequential diffusion were not found to clearly correlate with regional distribution dynamics. Conclusion: Acquisition of mutations upon SARS-CoV-2 spreading failed to explain regional diffusion heterogeneity at early pandemic times. Our findings indicate that COVID-19 transmission rates are rather associated with a sharp North/South climate gradient, with faster spreading in Southern regions. Thus, warmer climate conditions may not limit SARS-CoV-2 infectivity. Very cold regions may be better spared by recurrent courses of SARS-CoV-2 infection.
ABSTRACT
In this innovative practice full paper we present the implementation of the distant laboratory for the Internet of Things teaching and training. The recent outbreak of the SARS-COV-2 virus and related COVID-19 pandemic throughout the world has caused governments across the world to shut down schools and universities, to slow down the spread of the coronavirus that is causing the disease. As a result, some universities and schools have switched from physical classrooms to virtual or online classrooms. This approach is working well for theoretical subjects and courses, but it is not straight forward in the case of laboratory subjects and courses that require access to hardware resources. The IOT-OPEN.EU remote laboratory infrastructure presented in this paper is a timely solution. In this paper, we present current advances in distant learning, distant laboratory models, and the IOT-OPEN.EU remote laboratory implemented as part of the IOT-OPEN.EU ERASMUS+ project, along with short analysis on current advances in distant learning, where students are interacting with physical hardware remote way.